Resources & Insights
The science behind the medications, honest answers to common questions, and notes on what the trials actually show — written by clinicians, reviewed by clinicians, and updated as the evidence evolves.
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6 min read
The STEP 1 trial reported 14.9% mean weight loss with semaglutide. But "mean" hides as much as it reveals. Here's the response curve, the super-responders, the non-responders, and what the average actually means for an individual deciding whether to start.
Siam Clinic Weightloss Medical Team · Dr. Akkavich, M.D.
อ่านต่อ5 min read
No tapering protocol for GLP-1 medications is FDA-approved. But "expert taper" has become the standard approach in clinical practice. Here are the three methods we use — and the safety markers we check before starting.
Siam Clinic Weightloss Medical Team · Dr. Akkavich, M.D.
อ่านต่อ5 min read
"Doctor, will I gain it all back once I stop the injection?" The SURMOUNT-4 trial gives us the answer. Patients who stopped the drug regained 14% of their weight over the following year. But that's not the full picture — and it's not a 100% guarantee.
Siam Clinic Weightloss Medical Team · Dr. Akkavich, M.D.
อ่านต่อ4 min read
Without intervention, 25–40% of weight lost on GLP-1 medications can be lean muscle. For Asian patients — who already face unique metabolic risks at lower BMI — this isn't just cosmetic. It's a health crisis.
Siam Clinic Weightloss Medical Team · Dr. Akkavich, M.D.
อ่านต่อ4 min read
From my training in preventive medicine, I find this is the part patients most want to understand — and the part most marketing material skips. The patients who succeed long-term are almost always the ones who grasp the mechanism. Once you understand _why_ the drug is doing what it does, you stop fighting it.
Siam Clinic Weightloss Medical Team · Dr. Akkavich, M.D.
อ่านต่อ4 min read
Patients who treat these drugs as "fat burners" consistently underperform on body composition. Patients who treat them as appetite and metabolism modifiers — paired with high protein and resistance training — are the ones who reach goal weight with healthy muscle mass. The mechanism explains why.
Siam Clinic Weightloss Medical Team · Dr. Akkavich, M.D.
อ่านต่อPage 2 of 2 · 15 articles in total