Resources & Insights
The science behind the medications, honest answers to common questions, and notes on what the trials actually show — written by clinicians, reviewed by clinicians, and updated as the evidence evolves.
Searches titles and summaries only — not the body of the articles.
6 min read
The STEP 1 trial reported 14.9% mean weight loss with semaglutide. But "mean" hides as much as it reveals. Here's the response curve, the super-responders, the non-responders, and what the average actually means for an individual deciding whether to start.
Dr. Akkavich Harnnavachok
Read more5 min read
No tapering protocol for GLP-1 medications is FDA-approved. But "expert taper" has become the standard approach in clinical practice. Here are the three methods we use — and the safety markers we check before starting.
Dr. Akkavich Harnnavachok
Read more5 min read
"Doctor, will I gain it all back once I stop the injection?" The SURMOUNT-4 trial gives us the answer. Patients who stopped the drug regained 14% of their weight over the following year. But that's not the full picture — and it's not a 100% guarantee.
Dr. Akkavich Harnnavachok
Read more4 min read
Without intervention, 25–40% of weight lost on GLP-1 medications can be lean muscle. For Asian patients — who already face unique metabolic risks at lower BMI — this isn't just cosmetic. It's a health crisis.
Dr. Akkavich Harnnavachok
Read more4 min read
From my training in preventive medicine, I find this is the part patients most want to understand — and the part most marketing material skips. The patients who succeed long-term are almost always the ones who grasp the mechanism. Once you understand _why_ the drug is doing what it does, you stop fighting it.
Dr. Akkavich Harnnavachok
Read more4 min read
Patients who treat these drugs as "fat burners" consistently underperform on body composition. Patients who treat them as appetite and metabolism modifiers — paired with high protein and resistance training — are the ones who reach goal weight with healthy muscle mass. The mechanism explains why.
Dr. Akkavich Harnnavachok
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